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Agreement of treatment effects for mortality from routinely collected data and subsequent randomized trials: meta-epidemiological survey

BMJ 2016; 352 doi: http://www.libreriabv.com/10.1136/bmj.i493 (Published 08 February 2016) Cite this as: BMJ 2016;352:i493

Re: The authors respond

Hemkens et al. still do not acknowledge the bias of the inversion method that they used. This bias has nothing to do with regression to the mean. As a complement to the previously presented mathematical proof, we have posted a summary of some simulation results that may be easier to digest, indicating the magnitude and direction of the bias. It is available at http://www.libreriabv.com/faculty-staff-trainees/faculty/jessica-franklin/.

Competing interests: No competing interests

28 November 2017
Jessica M. Franklin
Assistant Professor of Medicine
Sara Dejene, Krista F. Huybrechts, Shirley V. Wang, Martin Kulldorff, and Kenneth J. Rothman
Brigham and Women's Hospital and Harvard Medical School
1620 Tremont St., Suite 3030, Boston, MA 02120
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